Dr. Dwivedi received his Ph.D. from the Central Drug Research Institute, India, a premier research institution with a focus of developing novel drugs. He completed his post-doctoral training at the Illinois State Psychiatric Research Institute. He began his career at the University of Illinois at Chicago as an Assistant Professor where he reached the rank of tenured Professor. He joined the Department of Psychiatry and Behavioral Neuroscience, University of Alabama at Birmingham in August 2013 as Elesabeth Ridgely Shook Endowed Chair in Psychiatry and tenured Professor and Director of Translational Research, UAB Mood Disorders Program. He has received numerous awards, and is a member of the National Institute of Mental Health study section; Scientific Advisory Council of American Foundation of Suicide Prevention; and Genetics and Neurobiology Task Force associated with International Association of Suicide Prevention. He is consistently funded by the National Institute of Mental Health and American Foundation for Suicide Prevention. He has published 130 papers, numerous book chapters and has edited a book “The Neurobiological Basis of Suicide.” He is on the editorial board of several scientific journals and has been invited to give various talks and symposia worldwide. He has been involved with AFSP since 2001. For the last 10 years, he has been a member of the Research Grants Committee for the National AFSP board. He has given several lectures at AFSP sponsored events on the neurobiological aspects of suicide.
Dr. Dwivedi’s research primarily focuses on understanding the neurobiological mechanisms associated with major depression and suicidal behavior. Major depression is among the most prevalent and recurrent form of psychiatric illnesses which affects about 17% of the population at some point in life and is associated with a high risk of suicide. Lifetime suicide attempt rate among adults is about 10% and suicide among teenagers is the 3rd leading cause of death. In order to increase the understanding of these disorders and identify new therapeutic targets and treatment approaches, Dr. Dwivedi’s lab is examining molecular and cellular nature of events in the brain that may lead to suicidal and depressive behavior. To achieve this, he is utilizing various approaches such as human postmortem brain studies, peripheral blood cell studies from patient population, rat brain studies involving manipulation of the stress axis, rodent models of depression and post-traumatic disorder, and gene knock-out mice.