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Characterizing the Role of tRNA Expression and Methylation in Proteomics Shifts of the Suicide Brain

2022 Young Investigator Grant
Amount Awarded: $90,000
Focus Area: Genetic Studies

Jennifer Blaze, Ph.D.

Jennifer Blaze, Ph.D.
Icahn School of Medicine at Mount Sinai

Mentor: Schahram Akbarian, M.D., Ph.D., Icahn School of Medicine at Mount Sinai

Inside the Research

Transfer (t)RNAs are clover-leaf shaped molecules that are crucial in translating the genetic code into functional proteins, and recent work suggests that dynamic chemical modifications to tRNAs may alter psychiatric outcomes. By identifying changes to these regulatory molecules in suicide and comparison human brain tissue, we will make strides in clarifying a novel biological marker and later consequences for psychiatric outcomes, potentially leading to predictors of suicidal behavior or better treatment options.