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2023 Focus Grant

Effectiveness of Diagnostic vs. Symptom-Only Suicide Crisis Syndrome Assessment (SCS-A) for Post-Discharge Suicide Prevention.

3 research findings from this AFSP-funded study.

Research finding · September 2026

Fear and isolation can prevent people from disclosing suicidal thoughts

Asking directly about suicidal thoughts is an important part of suicide prevention, but even a well-conducted assessment depends on whether someone is able and willing to share what they are experiencing. Research suggests that many people experiencing suicidal thoughts do not disclose them to clinicians, family members, friends, or anyone else. Some may fear judgment, hospitalization, or loss of autonomy, while others may feel ashamed, isolated, or unsure how to put their experience into words. In some cases, a suicidal crisis may also develop so quickly that there is little opportunity to tell someone beforehand. Understanding why people remain silent is therefore critical—not because disclosure can perfectly predict who will attempt suicide, but because reducing barriers to honest conversations can create more opportunities for connection, support, and intervention.

With AFSP funding, Dr. Igor Galynker and colleagues examined disclosure among 39 adults hospitalized in New York City following a suicide attempt, asking participants within seven days of their attempt whether they had previously shared their suicidal thoughts or intent with anyone. Nearly half (46%) reported that they had not. Among participants who described their reasons not to disclose, four themes emerged: fear of stigma or negative reactions, fear of consequences such as hospitalization or being stopped, isolation or having no one they felt able to talk to, and the sudden or impulsive nature of the attempt. Because participants were interviewed shortly after an attempt, the study offers a rare look at nondisclosure close to the time a suicidal crisis occurred rather than relying on memories months or years later. Although these findings require further research, they reinforce that asking about suicide is essential but may not always be enough. Creating environments where people feel safe disclosing, strengthening trusted social connections, and developing prevention strategies that do not depend solely on someone identifying and communicating their own risk may help create additional pathways to safety.

Citation: Garagiola, E. R., Bhatt, Y., Lawrence, H., Witerska, V., Rosen, T., Galynker, I., & Bloch-Elkouby, S. (2026). Patterns of suicidal ideation disclosure among acute psychiatric inpatients. Annals of general psychiatry, 25(1), 60. https://doi.org/10.1186/s12991-026-00669-y

This finding comes from an AFSP-funded study — see the grant below ↓

Research finding · November 2024

Various aspects of COVID-19 impacted the prevalence of suicidal crises behaviors

The Suicide Crisis Syndrome (SCS) is a psychological state identified as a potential precursor to suicidal behavior, particularly in individuals experiencing acute mental health crises. It was conceptualized by Dr. Igor Galynker as a framework to better predict imminent suicide risk and is characterized by a cluster of symptoms (e.g., feelings of entrapment, cognitive disturbance, extreme hopelessness, hyperarousal, social withdrawal) that are distinct from other mental health conditions, such as depression and anxiety. While many factors may influence the development of SCS, researchers have wondered if there is a relationship between global crises, such as the COVID-19 pandemic, and the incidence of SCS.

To explore the relationship between different aspects of the COVID-19 pandemic (e.g., peak daily cases and deaths, government responses and interventions) and SCS prevalence, Dr. Galynker collected data from 5528 adults across 10 countries using an anonymous web-based survey between June 2020 and January 2021. Participants with high SCS scores were more likely to be from countries with higher peak daily cases and deaths during the pandemic’s first wave. Additionally, longer exposure to the pandemic severity markers, such as prolonged lockdowns, were linked to a higher likelihood of screening positive for SCS. These findings were consistent across different countries and show that both the pandemic itself, and government responses to it, were associated with Suicide Crisis Syndrome.

Citation: Cohen, L. J., Liang, Y., Peterkin, D., McGibbon, K., Rappa, F., Rogers, M. L., You, S., Chistopolskaya, K., Enikolopov, S., Barzilay, S., Menon, V., Husain, M. I., Dudeck, M., Streb, J., Çinka, E., Yilmaz, F. K., Kuśmirek, O., Valvassori, S. S., Blum, Y., & Galynker, I. (2024). Relationship Between Severity and Length of Exposure to COVID-19 Parameters and Resulting Government Responses and the Suicide Crisis Syndrome (SCS). Disaster Medicine And Public Health Preparedness, 18, e68, Article e68. https://doi.org/10.1017/dmp.2023.235

This finding comes from an AFSP-funded study — see the grant below ↓

The grant behind this work · 2023 Focus Grant

Effectiveness of Diagnostic vs. Symptom-Only Suicide Crisis Syndrome Assessment (SCS-A) for Post-Discharge Suicide Prevention.

Igor Galynker, M.D., Ph.D.

Igor Galynker, M.D., Ph.D.

Icahn School of Medicine at Mount Sinai

Amount awarded
$1,500,000
Focus area
Psychosocial

Inside the Research

In preventing suicide, we rely on patients disclosing their suicidal intent. However, most people who died by suicide denied such intent during their final communications. The Suicide Crisis Syndrome (SCS) is a suicidal mental state that does not include suicidal intent, and its diagnosis is predictive of suicidal behavior or suicide death. The aim is to implement and compare the effectiveness of two different methods of assessing SCS for reducing suicidal behavior in the Mount Sinai Health System. 

Full scientific abstract

Background: Standard suicide risk assessments rely on self-reports of suicidal ideation (SI). However, up to 75% of suicide decedents explicitly deny SI during their final communications. Thus, implementation of imminent risk assessment tools not relying on SI is critical. The Suicide Crisis Syndrome (SCS) is an acute suicidal mental state under review for inclusion in the DSM as a suicide-specific diagnosis. SCS does not require SI, and the SCS Assessment (SCS-A) is uniquely predictive of suicidal behavior near-term post-hospital discharge. In emergency rooms, the abbreviated SCS-A was a preferred tool for clinical admission/discharge decision-making and associated with decreases in post-discharge suicidal outcomes.

Aims: We aim to implement and test the effectiveness of the SCS-A for reducing post-discharge suicidal behavior in a large urban hospital system. We will compare two implementation approaches: the Diagnosis (D) arm will use a categorical diagnosis of SCS to guide clinical decision making, whereas the Symptoms (S) arm will imbed SCS symptoms in the standard of care Mental Status Examination/Suicide Risk Assessment (MSE/SRA) without the SCS diagnosis, as recommended by some.

Hypotheses: We hypothesize that SCS-A implementation will result in decreased post-discharge suicidal outcomes in both arms compared to pre-implementation. This decrease will be larger in the D vs. S arm and will be mediated by the concordance of clinicians keep/discharge and intensify/not intensify treatment choices with the SCS diagnosis (Epic electronic health records) and with the self-reported use of SCS-A in choosing treatment (Epic). Both will be superior in the D vs. S arm.

Sample: We will analyze suicidal outcomes from Epic data for all inpatient admissions over the three-year study duration (expected N=7800). Additionally, we will recruit 930 ethnically and racially diverse high-risk adult Patient Participants (PPs), as well as 420 staff participants (SPs).

Measures: Patients primary suicidal outcomes will include one-month post-discharge suicide deaths, suicide attempts, emergency room visits and hospitalizations (Epic). Patients secondary suicidal outcomes will be SCS, SI, preparatory acts, and treatment utilization (in PPs). We will assess treatment decisions through Epic by the concordance (concordant=1; reverse=0) of 

keep/discharge and intensify/not intensify clinicians choices with the objective SCS diagnosis (explicit yes/no in the D arm, or implicit through the SCS criteria met in MSE/SRA in the S arm), as well as with the subjective self-reported use of SCS-A in choosing treatment (D and S arms).

Procedures: We will compare outcomes at four Mount Sinai Health System sites across four study phases: pre-implementation, implementation, post-implementation, and sustainability, using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Randomization will be enacted through Epic and each site will only get Epic templates specific to that study arm.

Impact: If our hypotheses are supported, we will establish that successful implementation of the diagnostic SCS-A in major urban health system improves suicide-related outcomes, establishing a blueprint for future multi-center SCS-A use using implementation science. In line with the AFSP goal of 20% by 2025, subsequent widespread implementation of diagnostic SCS-A, alongside traditional risk assessments, will have the potential to measurably reduce US suicide rates

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