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2020 Pilot Research Grant

Examining the Neurobiology of Suicidal Behavior in Adolescents

1 research finding from this AFSP-funded study.

Research finding · June 2026

A recent evidence update highlights progress in treatments for youth self-injury

Youth suicide and self-injury remain urgent public health concerns, and identifying treatments that meaningfully reduce suicidal thoughts and behaviors is a critical priority in child and adolescent mental health care. As new clinical trials are conducted, researchers regularly re-evaluate the strength of evidence supporting different interventions, examining whether findings replicate in multiple studies across settings, populations, and independent research teams. These evidence-based updates help clarify which treatments have the strongest support, which approaches remain promising and preliminary, and where additional research is still needed to improve care for youth experiencing suicide risk and self-injury.

With her AFSP-funded work, Dr. Catherine Glenn conducted a systematic review of randomized controlled trials published between 2018 and 2024 on psychosocial treatments for self-injurious thoughts and behaviors in youth. Using established evidence-rating criteria, treatments were classified across levels ranging from “experimental” and “possibly efficacious” to “probably efficacious” and “well-established,” based on factors such as replication, study quality, and consistency of results. The review found that Dialectical Behavior Therapy for Adolescents (DBT-A) remains the only well-established psychosocial treatment for reducing self-injurious thoughts and behaviors in youth, and was newly elevated to well-established status for reducing adolescent suicide attempts following additional successful randomized trials. Family Therapy was reclassified as probably efficacious for reducing suicidal ideation; and one cognitive behavioral therapy approach that combines individual and family components was reclassified as experimental for reducing suicide attempts due to inconsistent findings across studies. Several newer interventions, such as including emotion regulation, mindfulness, and safety-planning approaches, also showed encouraging but still developing evidence. Overall, the findings highlight both the meaningful progress and ongoing challenges involved in building a rigorous evidence base for youth suicide prevention treatments.

Citation: Erika C. Esposito, Kinjal K. Patel, Sunday Hull, Camille N. Johnson, Maya A. Patel & Catherine R. Glenn (2026): Evidence Base Update of Psychosocial Treatments for Self-Injurious Thoughts and Behaviors in Youth: 2018–2024, Journal of Clinical Child & Adolescent Psychology, https://doi.org/10.1080/15374416.2026.2613368

This finding comes from an AFSP-funded study — see the grant below ↓

The grant behind this work · 2020 Pilot Research Grant

Examining the Neurobiology of Suicidal Behavior in Adolescents

Catherine Glenn, Ph.D.

Catherine Glenn, Ph.D.

Harvard University

Amount awarded
$29,840
Focus area
Neurobiological, Psychosocial

Inside the Research

Bio: Dr. Glenn received her Ph.D. in clinical psychology from Stony Brook University in 2012. She is currently a NIMH Postdoctoral Fellow at Harvard University.

Research Categories: Neurobiological - brain functioning, Psychosocial

Abstract: The rate of suicidal behavior begins to increase during adolescence and this may be related to developmental changes in neurobiology and brain function at that time. Key neurobiological changes take place during adolescence: the subcortical brain region matures early, which relates to a person’s reward-focused behavior, while prefrontal systems in the brain are also still developing, which relates to behavioral control. In short, adolescents have too much ‘acceleration’ in without fully functioning ‘brakes’ in behavior.  This neurobiological model can explain to risk-taking behavior in these adolescents with depression. To increase our understanding of the relationship between brain development and suicidal behavior, Dr. Glenn will assess 40 adolescent females with major depression who are aged 13-17 years old, half of whom will have mad suicide attempt within the last year and half who report no history of suicidal ideation or suicide attempts. Functional magnetic resonance imaging (fMRI) will be used to measure brain function during tasks related to risk-taking and behavioral inhibition and control.  In addition, self-report measures will be administered to assess suicidal ideation and behavior as well as impulsiveness. The goal is to gain understanding about adolescents who are suicidal and have difficulty weighing reactivity to reward when they need to restrain their behavior.

Impact: Understanding of the neurobiological that may underlie suicidal behavior specifically in adolescents.

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