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Feasibility of Inhaled Nitrous Oxide Versus Intravenous Ketamine in TRD With Suicidal Ideation: A Pilot RCT

2022 Young Investigator Grant
Amount Awarded: $90,000
Focus Area: Clinical Treatment Studies

Venkat Bhat, M.D.

Venkat Bhat, M.D.
University of Toronto (Canada)

Mentor: Sidney Kennedy, M.D., University of Toronto (Canada)

Inside the Research

The proposed study is a randomized trial to compare a course of repeated nitrous oxide (N2O) inhalations to a course of repeated intravenous ketamine infusions for treatment-resistant depression with suicidal ideation. This will be an important step to identify the characteristics distinguishing the two treatments with some potential shared mechanism of action for patients at imminent risk of suicide. This study will provide feasibility, tolerability and preliminary efficacy estimates to aid the design of more definitive studies.