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Long-Term Maintenance with Ketamine Infusions for Reduction of Suicide in High-Risk Patients with Depression

2021 Focus Grant
Amount Awarded: $1,338,411
Focus Area: Clinical Treatment Studies

Cristina Cusin, M.D.

Cristina Cusin, M.D.
Massachusetts General Hospital

Inside the Research

Ketamine rapidly decreases depression and suicidal ideation. However, its effects on suicidal behaviors are unclear. Patients admitted to the hospital for suicidal ideation and behavior are at high risk for attempting suicide after discharge. This study will investigate the effectiveness of maintenance treatment with intravenous ketamine for 6 months. Outcomes will be compared with standard care for patients admitted to inpatient units for suicidal ideation and behavior and with an historical comparison group with no suicidal ideation or behavior.