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Mediating Effect of Genome-Wide Methylation in Conferring Risk for Suicide in Schizophrenia: A 1-year Follow-Up Study Monitoring Stress Exposure

2021 Standard Research Grant
Amount Awarded: $99,712
Focus Area: Genetic Studies

Vincenzo De Luca, M.D., Ph.D.

Vincenzo De Luca, M.D., Ph.D.
Centre for Addiction and Mental Health (Canada)

Inside the Research

Genes play a role in how one manages stress and may relate to suicidal ideation and behavior. This study will investigate molecular mechanisms that mediate the effect of stress exposure in contributing to suicidal ideation in patients with schizophrenia. The main outcome of this grant would be to learn about the molecular mechanisms that link stress to suicidal ideation. Our proposed study will highlight novel and potentially treatable molecular targets for the treatment of suicidal ideation in people with schizophrenia.