Research finding · February 2024
Genetic molecules may indicate risk for mood disorders and suicide
Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), are the most prevalent psychiatric conditions associated with an increased risk of suicide, but there are still questions around the underlying mechanisms. Genetic factors influence the way the brain functions and are thought to play a role in suicide risk through changes in the expression of particular microRNA (miRNAs), which are segments of genes that respond in real time to the environment. A recent aim in the field of genetic research involves unraveling the connection between miRNAs, mood disorders, and suicide. Understanding miRNAs may hold significant implications for the development of innovative treatments and strategies for preventing suicide.
With this in mind, Dr. Yogesh Dwivedi reviewed and synthesized previous studies that have contributed significant findings to our understanding of the role of miRNAs as potential biomarkers (biological indicators) for MDD, BD, and suicide risk. While acknowledging the potential of miRNAs to help predict and prevent suicide, Dr. Dwivedi identified challenges in using them in neuropsychiatry. Genetic differences in individuals related to medications, nutrition, and exposure to environmental conditions make it difficult to fully describe a population-wide role for specific miRNAs. He also noted that a promising method of study called Cerebrospinal Fluid-based Analysis may be too invasive and not practical large-scale use. Based on his review, Dr. Dwivedi recommended meticulous, long-term studies to validate findings.
Citation: Roy, B., Ochi, S., Dwivedi, Y. (2023) Potential of Circulating miRNAs as Molecular Markers in Mood Disorders and Associated Suicidal Behavior. International Journal of Molecular Sciences. 24, 4664. https://doi.org/10.3390/ijms24054664
This finding comes from an AFSP-funded study — see the grant below ↓
