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Research / Funded grants

2017 Young Investigator

Proximal Environmental Exposures for the Chronic Inflammation Suicide Subtype

2 research findings from this AFSP-funded study.

Research finding · May 2024

Relatives of individuals who died by suicide may have elevated levels of suicide risk

Suicide risk is complex, with a large range of potential risk factors including environmental and psychosocial factors, as well as biological influences such as genetics. Research has shown that having a family member who died by suicide could potentially contribute to suicide risk for family members. However, the majority of research indicating this has been conducted in Northwestern European countries due to the unique availability of health and multi-generational registries there. A comparative look is needed to see if this risk factor is also relevant in the United States, but U.S. data resources for studying familial risk are limited.

With this in mind, Dr. Amanda Bakian and her team examined data from the Utah Population Database, a unique repository of biomedical information that spans generations and degrees of familial relation. In her study, Dr. Bakian included all people in Utah who died by suicide between 1904 and 2014, and looked at over 2.1 million of their relatives. She then compared them to over 11.3 million relatives of people who did not die by suicide. Results indicated that the risk for suicide was higher in the family members (first- through fifth-degree relatives) of people who died by suicide. Dr. Bakian also found that risk levels were higher if the person who died by suicide was a young adult or woman. Understanding these familial patterns can help tailor public health interventions to target these specific groups more effectively.

Citation: Bakian, A. V., Chen, D., Coon, H., Docherty, A. R., Gray, D., Hanson, H. A., Keeshin, B., Smith, K. R., VanDerslice, J. A., Yu, D. Z., Zhang, C., & Zhang, Y. (2023). A population-wide analysis of the familial risk of suicide in Utah, USA. Psychological Medicine, 53(4), 1448-1457. https://doi.org/10.1017/S0033291721003020

This finding comes from an AFSP-funded study — see the grant below ↓

Research finding · August 2023

The genetics involved in suicide death and suicidal behavior differ

Over decades of investigation, genetic scientists in the field of suicide prevention research have built up a wealth of potential genetic indicators for suicide death and suicidal behavior. One approach that has been employed to garner this knowledge has been genome-wide association studies, which is a method of research that looks at genetic differences between a large group of people to find out which specific genes might be linked to certain traits or diseases.

With the aim of identifying genetic risk variants associated with suicide death and suicidal behavior, Dr. Amanda Bakian, along with other researchers in the International Suicide Genetics Consortium, conducted a meta-analysis and were able to identify different sets of markers for those who made suicide attempts, and individuals who died by suicide. These differences are important because most people who make a suicide attempt do not go on to die by suicide, and finding markers that may help identify individuals at risk for suicide death could lead to assessment and effective intervention.

Citation: Li, Q. S., Shabalin, A. A., DiBlasi, E., Gopal, S., Canuso, C. M., Palotie, A., Drevets, W. C., Docherty, A. R., Coon, H., & FinnGen, I. S. G. C. (2023). Genome-wide association study meta-analysis of suicide death and suicidal behavior. Molecular Psychiatry, 28(2), 891-900, http://dx.doi.org/10.1038/s41380-022-01828-9

This finding comes from an AFSP-funded study — see the grant below ↓

The grant behind this work · 2017 Young Investigator

Proximal Environmental Exposures for the Chronic Inflammation Suicide Subtype

Amanda Bakian, PhD

Amanda Bakian, Ph.D.

University of Utah

Mentor: Hilary Coon, Ph.D., University of Utah

Amount awarded
$83,795
Focus area
Neurobiological

Inside the Research

Question: Does chronic inflammation with sensitivity to environmental toxins indicate a subtype of suicide risk?

Strategy: Using a well-characterized database of suicide decedents in Utah, medical, psychiatric, genetic, and demographic data will be analyzed along with pollution and pollen exposure data.

Impact: Identification of a subtype of suicide with potential for targeted intervention.

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