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Sequencing small RNAs Underlying Epigenetic Regulation of Brain Gene Expression in Suicide

2018 Pilot Research Grant
Amount Awarded: $30,000
Focus Area: Genetic Studies

Yair Ben-Efraim, Ph.D.
Weizmann Institute of Science (Israel)

Inside the Research

Question: Does gene expression in the brain influence suicidal behavior?

Strategy: The ventromedial prefrontal cortex is a brain area associated with suicidal ideation and behavior. The functioning of genes, known as gene expression, in this brain area will be compared among four groups:  people who died by suicide or by other causes, and both with and without depression. Two measures of gene expression, RNA sequencing (RNASeq) and  real-time quantitative polymerase chain reaction (RT-qPCR), will used to measure gene expression.

Impact: Biomarkers specific to suicide risk for developing interventions.