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The Neuroimmunology of Suicide in Youth

2018 Standard Research Grant
Amount Awarded: $100,000
Focus Area: Neurobiological Studies

Vilma Gabbay, M.D., M.S.
Icahn School of Medicine at Mt. Sinai

Inside the Research

Question: How do anhedonia, inflammation, and brain circuitry contribute to suicidal behavior?

Strategy: Anhedonia (diminished pleasure), neuroimmunological processes, and brain cirucuitry (connections) will be compared among 30 adolescents with depression and a recent suicide attempt, 30 adolescents with non-suicidal depression, and 30 adolescents without a psychiatric history (HC), ages 12-17. Clinical evaluations, a blood test for measures of inflammation, and an MRI (imaging to assess brain function) will be conducted.

Impact: Identification of biological factors that could be the target of interventions to reduce youth suicide.