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Identification and Validation of Brain Relevant Blood-Based Biomarkers for Suicide in Major Depressive Disorder

2024 Blue Sky

Amount Awarded: $1,500,000

Focus Areas: , Genetic

Adolfo Sequeira, Ph.D.

Adolfo Sequeira, Ph.D.

University of California, Irvine

Inside the Research

This project aims to address the complex issue of suicide by developing blood-based biomarkers to assess suicide risk, particularly in individuals with Major Depressive Disorder (M.D.D). Utilizing post-mortem and clinical blood samples, the study will analyze gene expression and methylation patterns, integrating this multimodal data with machine learning algorithms. The goal is to identify suicide-specific molecular biomarkers, enhancing our understanding of immediate (gene expression) and enduring (methylation) molecular changes associated with suicide risk. This collaborative effort strives to establish effective predictors for suicide risk in clinical populations.